KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN6
All Species:
24.24
Human Site:
S557
Identified Species:
48.48
UniProt:
P29350
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29350
NP_002822.2
595
67561
S557
A
K
A
S
R
T
S
S
K
H
K
E
D
V
Y
Chimpanzee
Pan troglodytes
XP_001163468
596
67703
S558
A
K
A
S
R
T
S
S
K
H
K
E
D
V
Y
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
S559
A
K
A
S
R
T
S
S
K
H
K
E
D
V
Y
Dog
Lupus familis
XP_543844
595
67669
S557
A
K
A
S
R
T
S
S
K
H
K
E
D
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
P29351
595
67540
S557
A
K
A
S
R
T
S
S
K
H
K
E
E
V
Y
Rat
Rattus norvegicus
P81718
613
69560
S559
A
K
A
S
R
T
S
S
K
H
K
E
E
V
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519010
556
61792
E519
D
Q
I
N
Q
R
Q
E
S
L
P
H
P
G
P
Chicken
Gallus gallus
Q90687
593
67964
G555
S
L
S
D
Q
T
S
G
D
Q
S
P
L
P
P
Frog
Xenopus laevis
NP_001085766
594
68095
T555
S
A
G
E
R
A
R
T
K
A
Q
A
A
A
A
Zebra Danio
Brachydanio rerio
NP_956254
589
66986
K551
K
H
P
K
A
S
R
K
A
S
S
K
K
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
A687
Q
R
S
P
L
P
P
A
I
S
S
I
S
L
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
N496
I
L
S
P
A
I
L
N
E
D
K
N
V
Y
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.8
96.1
N.A.
94.4
91
N.A.
68
54.2
58.3
64.7
N.A.
33.8
N.A.
N.A.
43.3
Protein Similarity:
100
98.8
98.4
97.9
N.A.
98.1
94.9
N.A.
72.9
70.7
72
78.4
N.A.
46.9
N.A.
N.A.
60.8
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
0
13.3
13.3
0
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
33.3
33.3
13.3
N.A.
26.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
9
50
0
17
9
0
9
9
9
0
9
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
9
0
0
0
0
9
9
0
0
34
0
0
% D
% Glu:
0
0
0
9
0
0
0
9
9
0
0
50
17
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
0
0
9
0
0
0
0
0
9
0
% G
% His:
0
9
0
0
0
0
0
0
0
50
0
9
0
0
0
% H
% Ile:
9
0
9
0
0
9
0
0
9
0
0
9
0
0
0
% I
% Lys:
9
50
0
9
0
0
0
9
59
0
59
9
9
0
0
% K
% Leu:
0
17
0
0
9
0
9
0
0
9
0
0
9
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
9
0
0
0
9
0
9
0
% N
% Pro:
0
0
9
17
0
9
9
0
0
0
9
9
9
9
17
% P
% Gln:
9
9
0
0
17
0
9
0
0
9
9
0
0
0
9
% Q
% Arg:
0
9
0
0
59
9
17
0
0
0
0
0
0
0
0
% R
% Ser:
17
0
25
50
0
9
59
50
9
17
25
0
9
0
0
% S
% Thr:
0
0
0
0
0
59
0
9
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
9
50
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _